Effect of retinoic acid on cell surface glycopeptides of cultured spontaneously transformed mouse fibroblasts (BALB/c 3T12-3 cells).
نویسندگان
چکیده
منابع مشابه
Retinoid metabolism in spontaneously transformed mouse fibroblasts (Balb/c 3T12-3 cells): enzymatic conversion of retinol to anhydroretinol.
Spontaneously transformed mouse fibroblasts (Balb/c 3T12-3 cells) displayed an increased adhesion when cultured in the presence of 10(-6) M all-trans retinol and acquired morphological characteristics of the normal phenotype. Thus it was of interest to investigate the metabolism of [15-(14)C]retinol in this system. Within 24 hours of culture, approximately 4.25% of the [(14)C]retinol was taken ...
متن کاملEnhanced Na+-K+-activated adenosine triphosphatase activity in transformed fibroblasts.
tase was assayed in various lines of normal and transformed mouse and rat fibroblasts maintained in tissue culture. The rapidly growing, spontaneously transformed 3T6 and 3T12 cells derjved from mouse 3T3 fibroblasts, as well as 3T3 cells transformed by SV40 and murine sarcoma-murine leukemia viruses and XC cells, a line established from a Wistar rat tumor induced with Rous sarcoma, showed a 4t...
متن کاملThe development of mouse early embryos in vitro in fibroblasts and cumulus cells co-cultures supplemented with retinoic acid
This study was designed to examine the effects of retinoic acid adding to cumulus and/or fibroblast cellsmonolayer on the development of mouse early embryos. One-cell mouse embryos were obtained from NMRImice after superovulation by an intraperitoneal injection of 5 IU equine chorionic gonadotrophin (eCG)followed 48 hrs later by 5 IU human chorionic gonadotrophin (hCG). Mouse embryonic fibrobla...
متن کاملتاثیر غلظت‌های مختلف ال- ترانس رتینوئیک اسید بر رشد و بقای سلول‌های بنیادی فولیکول موی موش سوری
Background and Objective: Hair follicle stem cells are multipotent, located in the bulge area, and are highly proliferating. Retinoids have an effect on epidermal differentiation and keratinization. Retinoic acid is used to treat some skin diseases such as Melasma, Acne and Ichthyosis. So, the study of all-trans retinoic acid effect on hair follicle stem cells and determination of the effective...
متن کاملRetinoid metabolism and mode of action.
Vitamin A and its derivaties (retinoids) are necessary for the maintenance of normal phenotypic expression. An attempt at understanding the biochemical role of vitamin A had led to the demonstration of a new pathway for retinol. In this pathway, vitamin A is phosphorylated to retinylphosphate (RP), which is then glycosylated to retinylphosphatemannose (MRP). These two derivatives have been foun...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Cancer research
دوره 40 6 شماره
صفحات -
تاریخ انتشار 1980